Drug Targets

Conferences & Courses
Target Discovery for T Cell Therapy Target Discovery for T Cell Therapy
August 14, 2014 | Boston, MA
The Clinical Genome Conference, June 10-12, 2014 The unstoppable march of genomics into clinical practice continues.

Targeting Ocular Disorders Targeting Ocular Disorders
October 6-7, 2014 | Boston, MA
Targeting Ocular Disorders will address targeting of ophthalmic medications and treatments and will provide the latest results in the field, along with novel and emerging targets that hold promise in treating these crippling conditions.

Next-Generation Histone Deacetylase Inhibitors Next-Generation Histone Deacetylase Inhibitors
October 7, 2014 | Boston, MA
Next Generation Histone Deacetylase Inhibitors Symposium, part of Discovery on Target 2014 in Boston, presents the progress in HDAC chemistry, biology, screening and in bringing new inhibitors to the clinic.

Life Science Media Library
Allosteric Modulators of GPCRs Allosteric Modulators of GPCRs
September 23, 2013 |
Allosteric modulators represent a novel paradigm to therapeutically target G-protein-coupled receptors (GPCRs). However, identification and characterization of allosteric modulators using standard functional assays remain elusive due to the ‘context-dependent phenomena’. This course will discuss important aspects of hit identification and validation of allosteric modulators in GPCR research activity.
First Principles in Binding Kinetics First Principles in Binding Kinetics
June 6, 2012 |
This course will address the questions on “why should I care about kinetics?” and “how can I understand and predict Structure-Kinetics relationships?” We will first review the role of binding kinetics in drug action and then focus on the particular case of protein-ligand non-covalent complexes, reviewing what is known so far about the structural determinants of binding kinetics. This course will help you with a better understanding and increased awareness of current state of the chemistry and pharmacology of binding kinetics.
Pharmacology and Drug Discovery in the Allosteric World Pharmacology and Drug Discovery in the Allosteric World
November 3, 2011 |
The advancing technology of high-throughput screening is changing the type of molecules found. With protein function more physiologically relevant, the quality of the molecules that pharmacologists and medicinal chemists must deal with is changing. This course will familiarize researchers with the tools needed to exploit this potentially fruitful area of new drug discovery through discussion of allosteric molecules, detection of allosterism, and quantifying allosterism for chemical lead optimization.

Publications, Reports, & Whitepapers
MicroRNA: An Insight to miRNA-based microarrays, diagnostics and therapeutics
This report analyzes recent trends in medicinal chemistry and evaluates their significance for advancing R&D productivity. We consider technological modalities and market dynamics, with an emphasis on outsourcing and user views on the implications of current practices.